Nelson Group -- Publications


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*Publications*
Please note: Reprints are provided for personal use only.
		165. Leggett S.E., Brennan M.C., Martinez S., Tien J., & Nelson C.M. (2024) Relatively rare populations of invasive cells drive progression of heterogeneous tumors. Cell. Mol. Bioeng., in press.
		164. Nerger B.A. & Nelson C.M. (2024) Bioprinting cell-laden hydrogels for studies of epithelial tissue morphogenesis. In Tissue Morphogenesis (Methods in Molecular Biology), (ed. Nelson C.M.), in press.
		163. Banavar S. & Nelson C.M. (2023) Mechanical properties pattern the skin. Science, 382: 880. [pdf]
		162. Lemma B. & Nelson C.M. (2023) Spatial patterning of energy metabolism during tissue morphogenesis. Curr. Opin. Cell Biol., 85: 102235.
		161. Farahani P.E., Yang X., Mesev E.V., Fomby K.A., Brumbaugh-Reed E.H., Bashor C.J., Nelson C.M., & Toettcher J.E. (2023) pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells. eLife, 12: e82863. [pdf]
		160. Goodwin K. & Nelson C.M. (2023) Analysis of Cre lines for targeting airway smooth muscle. Dev. Biol., 496: 63-72. [pdf]
		159. Goodwin K., Lemma B., Zhang P., Boukind A., & Nelson C.M. (2023) Plasticity in airway smooth muscle differentiation during mouse lung development. Dev. Cell, 58: 338-347. [pdf] bioRxiv, DOI: https://doi.org/10.1101/2022.05.27.493761
		158. Dance Y.W., Obenreder M.C., Seibel A.J., Meshulam T., Ogony J.W., Lahiri N., Pacheco-Spann L., Radisky D.C., Layne M.D., Farmer S.R., Nelson C.M., Tien J. (2023) Adipose cells induce escape from an engineered human breast microtumor independently of their obesity status. Cell. Mol. Bioeng., 16: 23-39. [pdf]
		157. Paramore S.V., Goodwin K., & Nelson C.M. (2022) How to build an epithelial tree. Phys. Biol., 19: 061002. [pdf]
		156. Seibel A.J., Kelly O.M., Dance Y.W., Nelson C.M., Tien J. (2022) Role of lymphatic endothelium in vascular escape of engineered human breast microtumors. Cell. Mol. Bioeng., 15: 553-569. [pdf]
		155. Goodwin K., Jaslove J.M., Tao H., Zhu M., Hopyan S., & Nelson C.M. (2022) Patterning the embryonic pulmonary mesenchyme. iScience, 25: 103838. bioRxiv, DOI: https://doi.org/10.1101/2020.08.20.259101 [pdf]
		154. Nelson C.M. (2022) Mechanical control of cell differentiation: insights from the early embryo. Annu. Rev. Biomed. Eng., 24: 307-322. [pdf]
		153. Jaslove J.M., Goodwin K., Sundarakrishnan A., Spurlin J.W., Mao S., Kosmrlj A., & Nelson C.M. (2022) Transmural pressure signals through retinoic acid to regulate lung branching. Development, 149: dev199726. [pdf]
		152. Farahani P.E. & Nelson C.M. (2022) Revealing epithelial morphogenetic mechanisms through live imaging. Curr. Opin. Genet. Dev., 72: 61-68. [pdf]
		151. Leggett S.E. & Nelson C.M. (2022) Tissue architecture in cancer initiation and progression. In Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications, (eds. Akslen R.A. and Watnick R.S.), 91-107.
		150. Brennan M.C. & Nelson C.M. (2022) Cell patterning to mimic tumor anatomy. In Biomaterial based approaches to study the tumor microenvironment, (eds. Winter J.O. and Rao S.), 163-196.
		149. Dance Y.W., Meshulam T., Seibel A.J., Obenreder M.C., Layne M.D., Nelson C.M., & Tien J. (2022) Adipose stroma accelerates the invasion and escape of human breast cancer cells from an engineered microtumor. Cell. Mol. Bioeng., 15: 15-29. [pdf]
		148. Farahani P.E., Lemke S.B., Dine E., Uribe G., Toettcher J.E., & Nelson C.M. (2022) Substratum stiffness regulates Erk signaling dynamics through receptor-level control. Cell Rep., 37: 110181. [pdf]
		147. Palmer M.A., Nerger B.A., Goodwin K., Sudhakar A., Lemke S.B., Ravindran P., Toettcher J.E., Kosmrlj A., & Nelson C.M. (2021) Stress ball morphogenesis: how the lizard builds its lung. Sci. Adv., 7: eabk0161. [pdf]
		146. Stanton A.E., Goodwin K., Sundarakrishnan A., Jaslove J.M., Gleghorn J.P., Pavlovich A.L., & Nelson C.M. (2021) Negative transpulmonary pressure suppresses airway morphogenesis by inhibiting FGF10. Frontiers in Cell Dev. Biol., 9: 725785. [pdf]
		145. Lemke S.B. & Nelson C.M. (2021) How dynamic changes in epithelial cell packing shape tissues during morphogenesis. Curr. Biol., 31: R1098-R1110. [pdf]
		144. Silver B.B., Zhang S.X., Rabie E.M., & Nelson C.M. (2021) Substratum stiffness tunes membrane voltage in mammary epithelial cells. J. Cell Sci., 134: jcs256313.[pdf]
		143. Nelson C.M. (2021) The mechanics of crypt morphogenesis. Nat. Cell Biol., 23: 678-679.[pdf]
		142. Rabie E.M., Zhang S.X., Dunn C.E., & Nelson C.M. (2021) Substratum stiffness signals through integrin-linked kinase and beta1-integrin to regulate midbody proteins and abscission during EMT. Mol. Biol. Cell, 32: 1664-1676. [pdf] [supp]
		141. Nerger B.A., Jaslove J.M., Elashal H., Mao S., Kosmrlj A., Link A.J., & Nelson C.M. (2021) Local accumulation of extracellular matrix regulates global morphogenetic patterning in the developing mammary gland. Curr. Biol., 31: 1903-1917.[pdf]
		140. Leggett S.E. & Nelson C.M. (2021) Where is the EMT? Computer vision at the frontline of precision medicine. Trends Cancer, 7: 272.[pdf]
		139. Rabie E.M., Zhang S.X., Kourouklis A.P., Kilinc A.N., Simi A.K., Radisky D.C., Tien J., & Nelson C.M. (2021) Matrix degradation and proliferation are coupled to promote invasion and escape from an engineered human breast microtumor. Integr. Biol., 13: 17-29.[pdf][cover]
		138. Kilinc A.N., Han S., Barrett L.A., Anandasivam M. & Nelson C.M. (2021) Integrin-linked kinase tunes cell-cell and cell-matrix adhesions to regulate the switch between apoptosis and EMT downstream of TGFbeta1. Mol. Biol. Cell, 32: 402-412. [pdf]
		137. Goodwin K. & Nelson C.M. (2021) Mechanics of development. Dev. Cell, 20: 30934-5. [pdf]
		136. Goodwin K. & Nelson C.M. (2021) Uncovering cellular networks in branching morphogenesis using single-cell transcriptomics. Curr. Topics Dev. Biol., 143: 239-280. [pdf]
		135. Tien J., Dance Y.W., Ghani U., Seibel A.J., & Nelson C.M. (2021) Interstitial hypertension suppresses escape of human breast tumor cells via convection of interstitial fluid. Cell Mol. Bioeng., 14: 147-159. [pdf][cover]
		134. Tien J., Ghani U., Dance Y.W., Seibel A.J., Karakan M.C., Ekinci K.L., & Nelson C.M. (2020) Matrix pore size governs escape of human breast cancer cells from a microtumor to an empty cavity. iScience, 23: 101673. [pdf]
		133. Anlas A.A. & Nelson C.M. (2020) Living under strain: how epithelia protect their genomes from repeated stretching. Biochemistry, 4: 2761-2763. [pdf]
		132. Anlas A.A. & Nelson C.M. (2020) Soft microenvironments induce chemoresistance by increasing autophagy downstream of integrin-linked kinase. Cancer Res., 80: 4103-4113. [pdf]
		131. Silver B.B., Wolf A.E., Lee J., Pang M.-F., & Nelson C.M. (2020) Epithelial tissue geometry drives emergence of bioelectric field and pattern of proliferation. Mol. Biol. Cell, 31: 1691-1702.[pdf][cover]
		130. Palmer M.A. & Nelson C.M. (2020) Fusion of airways during avian lung development constitutes a novel mechanism for the formation of continuous lumena in multicellular epithelia. Dev. Dyn., 249: 1318-1333. [pdf]
		129. Nerger B.A., Brun P.-T., & Nelson C.M. (2020) Marangoni flows drive the alignment of fibrillar cell-laden hydrogels. Science Adv., 6(24): eazz7748.[pdf]
		128. Goodwin K. & Nelson C.M. (2020) Branching morphogenesis. Development, 147: dev184499.[pdf]
		127. Nerger B.A. & Nelson C.M. (2020) Engineered extracellular matrices: emerging strategies for decoupling structural and molecular signals that regulate epithelial branching morphogenesis. Curr. Opin. Biomed. Eng., 13: 103-112. [pdf]
		126. Goodwin K., Mao S., Guyomar T., Miller E., Radisky D.C., Kosmrlj A., & Nelson C.M. (2019) Smooth muscle differentiation shapes domain branches during mouse lung development. Development, 146: dev182188. [pdf]
		125. Spurlin J.W. III, Siedlik M.J., Nerger B.A., Pang M.F., Jayaraman S., Zhang R., & Nelson C.M. (2019) Mesenchymal proteases and tissue fluidity remodel the extracellular matrix during airway epithelial branching in the embryonic avian lung. Development, 146: dev175257. [pdf]
		124. Nerger B.A., Brun P.T., & Nelson C.M. (2019) Microextrusion printing cell-laden networks of type I collagen with patterned anisotropy and geometry. Soft Matter, 15: 5728-5738. [pdf] BioRxiv, DOI: https://doi.org/10.1101/509265
		123. Lehmann R., Lee C.M., Shugart E.C., Benedetti M., Charo R.A., Gartner Z., Hogan B., Knoblich J., Nelson C.M., & Wilson K.M. (2019) Human organoids: a new dimension in cell biology. Mol. Biol. Cell, 30: 1129-1137. [pdf]
		122. Nerger B.A. & Nelson C.M. (2019) 3D culture models for studying branching morphogenesis in the mammary gland and mammalian lung. Biomaterials, 198: 135-145. [pdf]
		121. Goodwin K. & Nelson C.M. (2018) Myoepithelial crowd control of cancer. J. Cell Biol., 217: 3319-3321. [pdf]
		120. Nelson C.M. (2018) Epithelial packing: Even the best of friends must part. Curr. Biol., 28: R1190-R1211. [pdf]
		119. Jaslove J.M. & Nelson C.M. (2018) Smooth muscle: a stiff sculptor of epithelial shapes. Phil. Trans. R. Soc. B., 373: 20170318. [pdf]
		118. Anlas A.A. & Nelson C.M. (2018) Tissue mechanics regulates form, function, and dysfunction. Curr. Opin. Cell Biol., 54: 98-105. [pdf]
		117. Kourouklis A.P. & Nelson C.M. (2018) Modeling branching morphogenesis using materials with programmable mechanical instabilities. Curr. Opin. Biomed. Eng., 6: 66-73. [pdf]
		116. Palmer M.A. & Nelson C.M. (2018) Epithelial tube fusion as a mechanism for the formation of complex lumen-containing organs. Trends Dev. Biol., 10: 57-69. [pdf]
		115. Han S., Pang M.F., & Nelson C.M. (2018) Substratum stiffness tunes proliferation downstream of Wnt3a in part by regulating integrin-linked kinase and frizzled-1. J. Cell Sci., 131, jcs210476. [pdf] [first person]
		114. Simi A.K., Anlas A.A., Stallings-Mann M., Zhang S., Hsia T., Cichon M., Radisky D.C., & Nelson C.M. (2018) A soft microenvironment protects from failure of midbody abscission and multinucleation downstream of the EMT-promoting transcription factor Snail. Cancer Res., 78: 2277-2289. [pdf] [cover]
		113. Silver B.B. & Nelson C.M. (2018) The bioelectric code: reprogramming cancer and aging from the interface of mechanical and chemical microenvironments. Frontiers Cell Dev. Biol., 6: 21. [pdf]
		112. Simi A.K., Pang M.F., & Nelson C.M. (2018) Extracellular matrix exists in a feedback loop that drives tumor progression. In Biomechanics in Oncology (eds. Kuhn N., Dong C., & Konstantopoulos K.), in press.
		111. Nelson C.M., Gleghorn J.P., Pang M.F., Jaslove J., Goodwin K., Varner V.D., Miller E., Radisky D.C., & Stone H.A. (2017) Microfluidic chest cavities reveal that transmural pressure controls the rate of lung development. Development, in 144: 4328-4335. [pdf]
		110. Piotrowski-Daspit A.S., Nerger B.A., Wolf A.E., Sundaresan S., & Nelson C.M. (2017) Dynamics of tissue-induced alignment of fibrous extracellular matrix. Biophys. J., 113: 702-713. [pdf]
		109. Siedlik M.J., Manivannan S., Kevrekidis I.G., & Nelson C.M. (2017) Cell division induces and switches coherent angular motion within bounded cellular collectives. Biophys. J., 112: 2419-2427. [pdf]
		108. Goodwin K. & Nelson C. M. (2017) Generating tissue topology through remodeling of cell-cell adhesions. Exp. Cell Res., 358: 45-51. [pdf]
		107. Nelson C. M. (2017) From static to animated: Measuring mechanical forces in tissues. J. Cell Biol., 216: 29-30. [pdf]
		106. Nerger B.A., Siedlik M.J., & Nelson C. M. (2017) Microfabricated tissues for investigating traction forces involved in cell migration and morphogenesis. Cell. Mol. Life Sci., 74: 1819-1834. [pdf]
		105. Spurlin J.W. & Nelson C. M. (2017) Building branched tissue structures: From single cell guidance to collective construction. Phil. Trans. R. Soc. B, 372: 20150527. [pdf]
		104. Piotrowski A.S., Simi A.K., Pang M.F., Tien J., & Nelson C.M. (2017) A three-dimensional culture model to study how fluid pressure and flow affect the behavior of aggregates of epithelial cells. In Mammary Gland Development (Methods in Molecular Biology series) (eds. Martin F. & Stein T.), 1501: 245-257. [pdf]
		103. Varner V.D. & Nelson C.M. (2017) Computational models of airway branching morphogenesis. Semin. Cell Dev. Biol., 67: 170-176. [pdf]
		102. Pang M.F., Siedlik M.J., Han S., Stallings-Mann M., Radisky D.C., & Nelson C.M. (2016) Tissue stiffness and hypoxia modulate the integrin-linked kinase (ILK) to control breast cancer stem-like cells. Cancer Res., 76: 1-11. [pdf]
		101. Tzou D., Spurlin J., Pavlovich A.L., Stewart C.R., Gleghorn J.P., & Nelson C.M. (2016) Morphogenesis and morphometric scaling of lung airway development follows phylogeny in chicken, quail, and duck embryos. EvoDevo, 7: 12. [pdf]
		100. Nelson C.M. (2016) Collective migration in tissues. Mol. Biol. Cell, 27: 877. [pdf]
		99. Piotrowski-Daspit A.S., Tien J., & Nelson C.M. (2016) Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin. Integr. Biol., 8: 319-331. [pdf]
		98. Navis A. & Nelson C.M. (2016) Pulling together: Tissue-generated forces that drive lumen morphogenesis. Semin. Cell Dev. Biol., 55: 139-147. [pdf]
		97. Piotrowski-Daspit A.S. & Nelson C.M. (2016) Engineering three-dimensional epithelial tissues embedded within extracellular matrix. JoVE, 113: e54283. [pdf]
		96. Nelson C.M. (2016) On buckling morphogenesis. J. Biomech. Eng., 138: 021005. [pdf]
		95. Siedlik M.J., Varner V.D., & Nelson C.M. (2016) Pushing, pulling, and squeezing our way to understanding mechanotransduction. Methods, 94: 4-12. [pdf]
		94. Pang M.F., Georgoudaki A.M., Lambu L., Johansson J., Tabor V., Hagikura K., Jin Y., Jansson M., Alexander J.S., Nelson C.M., Jakobsson L., Betsholtz C., Sund M., Karlsson M.C., & Fuxe J. (2015) TGFb1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by activation of CCR7/CCL21-mediated chemotaxis. Oncogene, 35: 748-760. [pdf]
		93. Kim H.Y., Pang M.F., Varner V.D., Kojima L., Miller E., Radisky D.C., & Nelson C.M. (2015) Localized smooth muscle differentiation is essential for epithelial bifurcation during branching morphogenesis of the mammalian lung. Dev. Cell, 34: 719-726. [pdf]
		92. Varner V.D., Gleghorn J.P., Miller E., Radisky D.C., & Nelson C.M. (2015) Mechanically patterning the embryonic airway epithelium. Proc. Natl. Acad. Sci. USA, 112: 9230-9235. [pdf] [supp]
		91. Gjorevski N., Piotrowski A.S., Varner V.D., & Nelson C.M. (2015) Dynamic tensile forces drive collective migration through three-dimensional extracellular matrices. Sci. Rep., 5: 11458. [pdf] [supp]
		90. Paluch E.K., Nelson C.M., Biais N., Fabry B., Moeller J., Pruitt B.L., Wollnik C., Krudyasheva G., Rehfeldt F., & Federle W. (2015) Four centuries of cells and mechanical forces. BMC Biology, 13: 47. [pdf]
		89. Cichon M.A., Nelson C.M., & Radisky D.C. (2015) Regulation of epithelial-mesenchymal transition in breast cancer cells by cell contact and adhesion. Cancer Informatics, 14: 1-13. [pdf]
		88. Siedlik M.S. & Nelson C.M. (2015) Regulation of tissue morphodynamics: an important role for actomyosin contractility. Curr. Opin. Genet. Dev., 32: 80-85. [pdf]
		87. Pang M.F. & Nelson C.M. (2015) Intercellular communication, the tumor microenvironment, and tumor progression. In Intercellular Communication in Cancer (ed. Kandouz M.), Springer, 343-362. [pdf]
		86. Boghaert E., Radisky D.C., & Nelson C.M. (2014) Lattice-based model of ductal carcinoma in situ suggests rules for breast cancer progression to an invasive state. PLOS Comp. Biol., 10: e1003997. [pdf]
		85. Simi A.K., Piotrowski A.S., & Nelson C.M. (2014) Mechanotransduction, metastasis, and genomic instability. In Genomic Instability and Cancer Metastasis: Mechanisms, Emerging Themes, and Novel Therapeutic Strategies (eds. Maxwell C. & Roskelley C.), 20: 139-158. [pdf]
		84. Varner V.D. & Nelson C.M. (2014) Cellular and physical mechanisms of branching morphogenesis. Development, 141: 2750-2759. [pdf]
		83. Schwarz U., Nelson C.M., & Silberzan P. (2014) Proteins, cells, and tissues in patterned environments. Soft Matter, 10: 2337-2340. [pdf]
		82. Jakus Z., Gleghorn J.P., Enis D., Sen A., Chia S., Liu X., Rawnsley D., Yang Y., Hess P., Zou Z., Yang J., Guttentag S., Nelson C.M., & Kahn M.L. (2014) Lymphatic vascular function is required perinatally for lung inflation at birth. J. Exp. Med., 211: 815-826. [pdf]
		81. Siedlik M.J. & Nelson C.M. (2014) Mechanics of tissue morphogenesis. In Cell and Matrix Mechanics (eds. Zemel A. & Kaunas R.), CRC Press, 285-308. [pdf]
		80. Varner V.D. & Nelson C.M. (2014) Toward the directed self-assembly of engineered tissues. Annu. Rev. Chem. Biomol. Eng., 5: 507-526. [pdf]
		79. Tien J. & Nelson C.M. (2014) Microstructured extracellular matrices in tissue engineering and development, an update. Ann. Biomed. Eng., 42: 1413-1423. [pdf]
		78. Kim H.Y. & Nelson C.M. (2014) Epithelial engineering: from sheets to branched tubes. In Bio-Inspired Materials for Biomedical Engineering (eds. Kirscher C.M. & Brennan A.B.), 161-173.
		77. Piotrowski A., Varner V.D., Gjorevski N., & Nelson C.M. (2014) Three-dimensional traction force microscopy of engineered epithelial tissues. In Tissue Morphogenesis (Methods in Molecular Biology series) (ed. Nelson C.M.) (Springer, New York), 1189: 191-206. [pdf]
		76. Lee K. & Nelson C.M. (2014) Determining the role of matrix compliance in the differentiation of mammary stem cells. In Biomimetics and Stem Cells: Methods and Protocols (Methods in Molecular Biology series) (eds. Vunjak-Novakovic G., Turksen K.) (Springer, New York), 1202: 79-94. [pdf]
		75. Nelson C.M. (2013) Forces in epithelial origami. Dev. Cell, 26: 554-556. [pdf]
		74. Varner V.D. & Nelson C.M. (2013) Let's push things forward: disruptive technologies and the mechanics of tissue assembly. Integr. Biol., 5: 1162-1173. [pdf]
		73. Kim H.Y., Varner V.D., & Nelson C.M. (2013) Apical constriction initiates new bud formation during monopodial branching of the embryonic chicken lung. Development, 140: 3146-3155. [pdf]
		72. Zhu W. & Nelson C.M. (2013) PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively. Dev. Biol., 379: 235-245. [pdf]
		71. Radisky D.C. & Nelson C.M. (2013) Regulation of mechanical stress by mammary epithelial tissue structure controls breast cancer cell invasion. Oncotarget, 4: 498-499. [pdf]
		70. Gleghorn J.P., Manivannan S., & Nelson C.M. (2013) Quantitative approaches to uncover physical mechanisms of morphogenesis. Curr. Opin. Biotechnol., 24: 954-961. [pdf]
		69. Zhu W. & Nelson C.M. (2013) Adipose and mammary epithelial tissue engineering. Biomatter, 3: e24630. [pdf]
		68. Chen Q.K., Lee K., Radisky D.C., & Nelson C.M. (2013) Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. Differentiation, 86: 126-132.
		67. Mori H., Lo A.T., Ghajar C.M., Inman J.L., Alcaraz J., Chen C.S., Nelson C.M., Zhang H., Mott J.D., Bascom J.L., Seiki M., & Bissell M.J. (2013) Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin beta1. Development, 140: 343-352. [pdf][supp]
		66. Boghaert E., Gleghorn J.P., Lee K., Gjorevski N., Radisky D.C., & Nelson C.M. (2012) Host epithelial geometry regulates breast cancer cell invasiveness. Proc. Natl. Acad. Sci. USA, 109: 19362-19367. [pdf][supp]
		65. Nelson C.M. (2012) Symmetry breaking during morphogenesis in the embryo and in engineered tissues. AIChE J., 58: 3608-3613. [pdf][cover]
		64. Tien J., Truslow J.G., & Nelson C.M. (2012) Modulation of invasive phenotype by interstitial pressure-driven convection in aggregates of human breast cancer cells. PLOS ONE, 7: e45191. [pdf]
		63. Lee K., Chen Q.K., Lui C., Cichon M.A., Radisky D.C., & Nelson C.M. (2012) Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition. Mol. Biol. Cell, 23: 4097-4108. [pdf][supp][cover]
		62. Manivannan S. & Nelson C.M. (2012) Dynamics of branched tissue assembly. Stem Cell Res. Ther., 3: 42. [pdf]
		61. Gjorevski N. & Nelson C.M. (2012) Mapping of mechanical strains and stresses around quiescent engineered three-dimensional epithelial tissues. Biophys. J., 103: 152-162. [pdf][supp]
		60. Zhu W. & Nelson C.M. (2012) PI3K signaling in the regulation of branching morphogenesis. BioSystems, 109: 403-411. [pdf]
		59. Gleghorn J.P., Kwak J., Pavlovich A.L., & Nelson C.M. (2012) Inhibitory morphogens and monopodial branching of the embryonic chicken lung. Dev. Dyn., 241: 852-862. [pdf]
		58. Kim H.Y. & Nelson C.M. (2012) Extracellular matrix and cytoskeletal dynamics during branching morphogenesis. Organogenesis, 8: 56-64. [pdf]
		57. Chung J.W., Lee K., Neikirk C., Nelson C.M., & Priestley R.D. (2012) Photo-responsive coumarin-stabilized polymeric nanoparticles as a detectable drug carrier. Small, 8: 1693-1700. [pdf]
		56. Nelson C.M. & Gleghorn J.P. (2012) Sculpting organs: Mechanical regulation of tissue development. Annu. Rev. Biomed. Eng., 14: 129-154. [pdf]
		55. Nelson C.M. (2012) Bioengineering and mechanobiology: pushing (and pulling) the limits of cellular mechanics. Mol. Biol. Cell, 23: 969. [pdf]
		54. Lui C., Lee K., & Nelson C.M. (2012) Matrix compliance and RhoA direct the differentiation of mammary progenitor cells. Biomech. Model. Mechanobiol., 11: 1241-1249. [pdf]
		53. Gjorevski N., Boghaert E., & Nelson C.M. (2012) Regulation of epithelial-mesenchymal transition by transmission of mechanical stress through epithelial tissues. Cancer Microenvironment, 5: 29-38. [pdf]
		52. Gleghorn J.P. & Nelson C.M. (2012) Nanopatterned surfaces for exploring and regulating cell behavior. Encyclopedia Nanotech., (ed. Bhushan B.) (Springer, New York), pp. 1670-1678. [pdf]
		51. Manivannan S., Gleghorn J.P., & Nelson C.M. (2012) Engineered tissues to quantify collective cell migration during morphogenesis. In Kidney Development: Methods and Protocols (Methods in Molecular Biology vol. 886) (ed. Michos O.) (Springer, New York), pp. 173-182. [pdf]
		50. Cung K., Slater R.L., Cui Y., Manivannan S., Jones S.E., Ahmad H., Nelson C.M., Naik R.R., & McAlpine M.C. (2012) Rapid, multiplexed microfluidic phage display. Lab Chip, 12: 562-565. [pdf]
		49. Lee K. & Nelson C.M. (2012) New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis. Int. Rev. Cell Mol. Biol., 294: 169-219. [pdf]
		48. Gjorevski N. & Nelson C.M. (2011) Integrated morphodynamic signalling of the mammary gland. Nat. Rev. Mol. Cell Biol., 12: 581-593. [pdf]
		47. Lee K., Gjorevski N., Boghaert E., Radisky D.C., & Nelson C.M. (2011) Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis. EMBO J., 30: 2662-2674. [pdf][supp]
		46. Pavlovich A.L., Boghaert E., & Nelson C.M. (2011) Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFbeta in culture. Exp. Cell Res., 317: 1872-1884. [pdf]
		45. Gomez E.W. & Nelson C.M. (2011) Lithographically-defined two- and three-dimensional tissue microarrays. In Biological Microarrays (Methods in Molecular Biology, vol. 671) pp. 107-116 (eds. Khademhosseini A., Suh K.-Y., & Zourob M.) (Springer, New York). [pdf]
		44. Raghavan S., Shen C.J., Desai R.A., Sniadecki N.J., Nelson C.M., & Chen C.S. (2010) Decoupling diffusional from dimensional control of signaling in 3D culture reveals a role for myosin in tubulogenesis. J. Cell Sci., 123: 2877-2883. [pdf]
		43. Gjorevski N. & Nelson C.M. (2010) Endogenous patterns of mechanical stress are required for branching morphogenesis. Integr. Biol., 2: 424-434. [pdf][supp]
		42. Pavlovich A.L., Manivannan S., & Nelson C.M. (2010) Adipose stroma induces branching morphogenesis of engineered epithelial tubules. Tissue Eng. Part A, 16: 3719-3726. [pdf]
		41. Boghaert E. & Nelson C.M. (2010) Tumor microenvironment and host/stroma interactions: Guidelines for physical modeling. in Biophysical Modeling of Cancer in Silico (ed. Cristini V.), in press (Springer, New York).
		40. Gjorevski N. & Nelson C.M. (2010) The mechanics of development: models and methods for tissue morphogenesis. Birth Defects Res. C Embryo Today, 90: 193-202. [pdf]
		39. Liu Z., Tan J.L., Cohen D.M., Yang M.T., Sniadecki N.J., Ruiz S.A., Nelson C.M., & Chen C.S. (2010) Mechanical tugging forces regulate the size of cell-cell junctions. Proc. Natl. Acad. Sci. USA, 107: 9944-9949. [pdf][supp]
		38. Raghavan S., Nelson C.M., Baranski J.D., Lim E., & Chen C.S. (2010) Geometrically controlled endothelial tubulogenesis in micropatterned gels. Tissue Eng. Part A, 16: 2255-2263. [pdf]
		37. Gjorevski N. & Nelson C.M. (2010) Branch formation during organ development. Wiley Interdiscip. Rev. Systems Biol. Med., 2: 734-741. [pdf]
		36. Gomez E.W., Chen Q.K., Gjorevski N., & Nelson C.M. (2010) Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. J. Cell. Biochem., 110: 44-51. [pdf][supp][cover]
		35. Mori H., Gjorevski N., Inman J.L., Bissell M.J., & Nelson C.M. (2009) Self-organization of engineered epithelial tubules by differential cellular motility. Proc. Natl. Acad. Sci. USA, 106: 14890-14895. [pdf][supp]
		34. Gjorevski N. & Nelson C.M. (2009) Bidirectional extracellular matrix signaling during tissue morphogenesis. Cytokine Growth Factor Rev., 20: 459-465. [pdf]
		33. Chen C.S., Nelson C.M., Khauv D., Bennett S., Radisky E.S., Hirai Y., Bissell M.J., & Radisky D.C. (2009) Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis. J. Biol. Chem., 284: 6877-6884. [pdf][cover]
		32. Nelson C.M. (2009) Geometric control of tissue morphogenesis. Biochim. Biophys. Acta, 1793: 903-910. [pdf]
		31. LaBarge M.A., Nelson C.M., Villadsen R., Fridriksdottir A., Ruth J.R., Stampfer M.R., Petersen O.W., & Bissell M.J. (2009) Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr. Biol., 1: 70-79. [pdf][cover]
		30. Xu R., Nelson C.M., Muschler J.L., Vonderhaar B.K., & Bissell M.J. (2009) Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. J. Cell Biol., 184: 57-66. [pdf]
		29. Alcaraz J., Xu R., Mori H., Nelson C.M., Mroue R., Spencer V.A., Brownfield D., Radisky D.C., Bustamante C., & Bissell M.J. (2008) Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J., 27: 2829-2838. [pdf]
		28. Gray D.S., Liu W.F., Shen C.J., Bhadriraju K., Nelson C.M., & Chen C.S. (2008) Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton. Exp. Cell. Res., 314: 2846-2854. [pdf]
		27. Nelson C.M., Khauv D., Bissell M.J., & Radisky D.C. (2008) Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J. Cell. Biochem., 105: 25-33. [pdf][cover]
		26. Nelson C.M., Inman J.L., & Bissell M.J. (2008) Three-dimensional lithographically-defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression. Nat. Protoc., 3: 674-678. [pdf]
		25. Liu W.F., Nelson C.M., Tan J.L., & Chen C.S. (2007) Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ. Res., 101: e44-52. [pdf]
		24. Hirai Y., Nelson C.M., Yamazaki K., Takebe K., Przybylo J., Madden B., & Radisky D.C. (2007) The non-classical export of epimorphin and its adhesion to alpha-v-integrin for regulation of epithelial morphogenesis. J. Cell Sci., 120: 2032-2043. [pdf]
		23. LeBeyec J., Xu R., MoonLee S.Y., Nelson C.M., Rizki A., Alcaraz J., & Bissell M.J. (2007) Cell shape regulates global histone acetylation in human mammary epithelial cells. Exp. Cell Res., 313: 3066-3075. [pdf]
		22. Itoh M., Nelson C.M., Myers C.A., & Bissell M.J. (2007) Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. Cancer Res., 67: 4759-4766. [pdf][cover]
		21. Nelson C.M., VanDuijn M.M., Inman J.L., Fletcher D.A., & Bissell M.J. (2006) Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science, 314: 298-300. [pdf][supp]
		20. Nelson C.M. & Tien J. (2006) Microstructured extracellular matrices in tissue engineering and development. Curr. Opin. Biotech., 17: 518-523. [pdf]
		19. Liu W.F., Nelson C.M., Pirone D.M., & Chen C.S. (2006) E-cadherin engagement stimulates proliferation via Rac1. J. Cell Biol., 173: 431-441. [pdf][supp]
		18. Nelson C.M. & Bissell M.J. (2006) Of extracellular matrix, scaffolds, and signaling: Tissue architecture regulates development, homeostasis, and cancer. Annu. Rev. Cell Dev. Biol., 22: 287-309. [pdf]
		17. Kenny P.A., Nelson C.M., & Bissell M.J. (2006) The ecology of tumors. The Scientist, April: 30-37. [pdf]
		16. Liu H., Radisky D.C., Nelson C.M., Zhang H., Fata J.E., Roth R.A., & Bissell M.J. (2006) Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc. Natl. Acad. Sci. USA, 103: 4134-4139. [pdf][supp]
		15. Nelson C.M., Liu W.F., & Chen C.S. (2006) Manipulation of cell-cell adhesion using bowtie-shaped microwells. Adhesion Protein Protocols (Methods in Molecular Biology, Vol. 96), 1-10. [pdf]
		14. Nelson C.M., Jean R.P., Tan J.L., Liu W.F., Sniadecki N.J., Spector A.A., & Chen C.S. (2005) Emergent patterns of growth controlled by multicellular form and mechanics. Proc. Natl. Acad. Sci. USA, 102: 11594-11599. [pdf][supp]
		13. Radisky D.C., Levy D.D., Littlepage L.E., Liu H., Nelson C.M., Fata J.E., Leake D., Godden E.L., Albertson D.G., Nieto M.A., Werb Z., & Bissell M.J. (2005) Rac1b and reactive oxygen species mediate MMP3-induced EMT and genomic instability. Nature, 436: 123-127. [pdf]
		12. Nelson C.M, & Bissell M.J. (2005) Modeling dynamic reciprocity: Engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin. Cancer Biol., 15: 342-352. [pdf]
		11. Alcaraz J., Nelson C.M., & Bissell M.J. (2004) Biomechanical approaches for studying integration of tissue structure and function in mammary epithelia. J. Mammary Gland Biol. Neoplasia, 9: 361-374. [pdf]
		10. Tan J.L., Liu W., Nelson C.M., Raghavan S., & Chen C.S. (2004) Simple approach to micropattern cells on common culture substrates by tuning substrate wettability. Tissue Eng., 10: 865-872. [pdf]
		9. Nelson C.M., Pirone D.M., Tan J.L., & Chen C.S. (2004) Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA. Mol. Biol. Cell, 15: 2943-2953. [pdf][supp]
		8. McBeath R., Pirone D.M., Nelson C.M., Bhadriraju K., & Chen C.S. (2004) Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell, 6: 483-495. [pdf]
		7. Nelson C.M. & Chen C.S. (2003) VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. J. Cell Sci., 116: 3571-3581. [pdf][cover]
		6. Nelson C.M. & Chen C.S. (2003) Engineering cell adhesion for biotechnology applications. Chem. Eng. Tech., in press. [pdf]
		5. Nelson C.M., Raghavan S., Tan J.L., & Chen C.S. (2003) Degradation of micropatterned surfaces by cell-dependent and -independent processes. Langmuir, 19: 1493-1499. [pdf]
		4. Tan J.L., Nelson C.M., Gray D.S., & Chen C.S. (2002) Approaches to organize cells on surfaces. IEEE Engineering in Medicine and Biology Magazine, 101-103. [pdf]
		3. Nelson C.M. & Chen C.S. (2002) Cell-cell contact increases cell proliferation via a PI3K-dependent signal. FEBS Letters, 514: 238-242. [pdf]
		2. Tien J., Nelson C.M., & Chen C.S. (2002) Fabrication of aligned microstructures with a single elastomeric stamp. Proc. Natl. Acad. Sci. USA, 99: 1758-1762. [pdf][cover]
		1. Asthagiri A.R., Nelson C.M., Horwitz A.F., & Lauffenburger D.A. (1999) Quantitative relationship among integrin-ligand binding, adhesion, and signaling via focal adhesion kinase and extracellular-signal regulated kinase 2. J. Biol. Chem., 274: 27119-27127. [pdf]

Nelson Group, Department of Chemical & Biological Engineering, Princeton University